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There is an important difference between an advance in science and ach — Fred Hoyle

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"There is an important difference between an advance in science and achievements in the humanities. A great musician consumes intellectual capital, he does not supply it, or at least it is usual for him to consume more than he creates. It has been impossible to use the motto theme of the Fifth Symphony after Beethoven used it. In science, on the other hand, the situation is the other way round. A breakthrough invariably opens up more new problems to be solved. A Newton or an Einstein may leave the world with a century or more of clearing up to be done."
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Fred Hoyle
Fred Hoyle
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Sir Fred Hoyle (24 June 1915 – 20 August 2001) was an English astronomer. With Margaret and Geoffrey Burbidge and William Alfred Fowler, he formulated the theory of stellar nucleosynthesis in the influential B2FH paper.

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"To achieve anything really worthwhile in research it is necessary to go against the opinions of ones fellows. To do so successfully, not merely becoming a crackpot, requires fine judgement, especially on long-term issues that cannot be settled quickly. ...To hold popular opinion is cheap, costing nothing in reputation, whereas to accept that there is evidence pointing oppositely... is to risk scientific tar and feathers. Yet not to take the risk is to make certain that, if something new is really there, you wont be the one to find it."
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Fred Hoyle